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Recommended Dose: Adults: Initial Dose: The recommended starting dose is 30 mg/day.
Titration: Dosage adjustments should ordinarily be in increments of 30 mg, as determined by blood glucose response. The interval between dose increases of modified-release preparation should be at least 1 month, but the dose may be increased after just 2 weeks in those patients who have not responded.
Maximum Dose: 120 mg once daily.
Children: There are no data and clinical studies available in children.
Geriatric: Refer to adult dosing; use with caution.
Renal impairment: Mild to moderate renal impairment: The same dosing regimen can be used as in patients with normal renal function with careful patient monitoring.
Severe renal impairment: Use is contraindicated.
Mode of Administration: Gliclazide is administered orally. Modified-release tablets of the drug should be administrated with breakfast. Modified release tablets should not be crushed or chewed.
If a dose is forgotten, there must be no increase in the dose taken the next day.
The tablet can be divided into equal doses.
